Characterization of monkey V1 local field potentials as recorded by different types of chronically implanted multi-electrode arrays D Wegener1, S Mandon1, V Gordillo-González1, F O Galashan1, E Erdogdu1, Y Smiyukha1, I Grothe2, A K Kreiter1 |
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1Theoretical Neurobiology, Institute for Brain Research, University of Bremen, Germany |
| Chronically implanted multielectrode arrays (MEAs) allow studying dynamic interactions within large neuronal populations. They have become an important tool in basic neuroscience and constitute a promising approach for future neuroprosthetic and –therapeutic applications. The majority of current arrays use intracortically implanted electrodes that allow recording both single unit activity and local field potentials. For medical purposes, however, epidurally implanted electrodes are more favorable since they do not penetrate dura or nervous tissue. Here, we investigate different chronic approaches with a focus on two issues: first, comparison of the stimulus specificity of local field potentials recorded either intracortically or epidurally, and second, long-term stability of recordings. Responses from primary visual cortex were recorded by four different MEA types and were obtained for prolonged periods of time, lasting to a maximum of six years. The results show that epidurally recorded LFPs possess a high stimulus specificity closely resembling that of intracortically recorded LFPs and can be detected with high reliability even many years after implantation. Thus, epidural electrode matrices fulfill an important pre-requisite to use intracranial neural signals for medical purposes. |
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