The Detection and Discrimination of Objects in Patients with Schizophrenia treated with Atypical and Typical Drugs I Shoshina, Y Shelepin |
|---|
Pavlov Institute of Physiology, RAS, Russian Federation
|
| We are study the influence of different antipsychotic drugs on the magno- and parvocellular visual channels. We measured the contrast sensitivity and magnitude of the Muller-Lyer illusion in normal observers and schizophrenic patients. We used the Gabor gratings and images of the Muller-Lyer figure after they were digitally wavelet filtered. Both types of stimuli have the same ranges of spatial frequency (0.4, 3.6 and 17.9 cycle/degree). Patients were divided into two groups. The first group consisted of patients treated with atypical antipsychotic drugs, the second group – typical drugs. In both groups of patients we see the decline of sensitivity in the range of low and medium spatial frequencies in comparison with the norm. The patients treated with the atypical drugs showed the same sensitivity to the Muller-Lyer illusion as in the norm when the arrows of stimulus were presented in low spatial frequency range, whereas the patients with the typical drugs treatment showed higher magnitude of the illusion, than healthy. We demonstrate the significant differences of sensitivity in the range of low spatial frequencies between two groups of patients. It may be a result of different selective effect of typical and atypical drugs on visual channels. |
| Up Home |
|---|