Electrophysiological examination of patient with partial recovery of vision after 53 years of blindness J Kremlacek1, R Sikl2, M Kuba1, J Szanyi1, Z Kubova1, J Langrova1, F Vit1, M Simecek2, P Stodulka3 |
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1Faculty of Medicine in Hradec Kralove, Charles University in Prague, Czech Republic |
| 72-year-old subject KP lost his sight at the age of 17 years, and light projection onto his right retina was restored after 53 years of visual deprivation by a corneal implant. Nine months after sight recovery we had opportunity to examine his vision using electrophysiology tests assessing the effect of long-term deprivation on a mature visual system. In spite of degraded vision and sensory deprivation lasting 53 years and partial retinal detachment we recorded reliable and reproducible responses to all used stimuli after their adjustment to KP’s vision. The KP’s responses were compared to results of two age matched control subjects, to whom the stimuli were adjusted in size and contrast to mimic KP’s vision. Both VEP variants were significantly delayed in comparison to the controls’ responses. However, the KP’s time interval between sensory detection and the cognitive component (P3b/P300) of the ERP to a target event in the visual oddball paradigm was not further delayed. Long-term visual deprivation and retinal detachment degraded KP’s electrophysiological markers of visual sensory processing, whereas the cognitive processing of appropriate visual stimuli was not compromised (Kremlacek J et al., Vis Research, 2013). Supported by Grant Agency of the Czech Republic 309/09/0869 and 407/12/2528. |
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